Medically the review by Darren Hein, PharmD — written by college of Illinois — to update on September 2, 2018


Mucinex and Nyquil Cold & Flu room two common, over-the-counter remedies friend can uncover on her pharmacist’s shelf. Compare the symptoms that each drug treats and their side effects, interactions, and also warnings to watch if one is a better option for you.

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The main differences between these drugs space their active ingredients and how those job-related to treat her symptoms.

Mucinex treats chest congestion. The main active ingredient is one expectorant referred to as guaifenesin. It works by thinning the consistency of rubber in your air passages. This loosens up rubber in your chest for this reason you can cough that up and also out.

NyQuil temporary treats common cold and also flu symptom such as fever, cough, sleep congestion, boy aches and pains, headache, and runny nose and also sneezing. The active ingredients space acetaminophen, dextromethorphan, and doxylamine. This ingredients each work a little differently.

For example, paracetamol is a pain reliever and fever reducer. It alters the way your body senses pain and also regulates temperature. Dextromethorphan suppresses the signal in your brain that create your coughing reflex. Doxylamine, ~ above the various other hand, block a problem in her body dubbed histamine. This substance causes allergy symptoms such as itchy, watery eyes, runny nose, and itchy sleep or throat. Together, this ingredients carry out the relief you can gain from NyQuil.

The adhering to table summarizes the differences in between Mucinex and NyQuil at a glance.

Active ingredient(s)guaifenesinacetaminophen, dextromethorphan, doxylamine
Symptom(s) treatedchest congestionfever, cough, nasal congestion, young aches and pains, headache, sick throat, runny nose, sneezing
Usagethroughout the dayat night
Formsextended-release dental tablet*, oral granulesoral liquid capsule, dental solution
Risk the interactionsnoyes
Risk of significant side effectsnoyes

*There is likewise an extra-strength form of this tablet, which has twice as lot of the energetic ingredient.

Forms and also dosage

You can use Mucinex transparent the day, but you generally use NyQuil at night to help you sleep and let her body recover. The ingredient doxylamine in NyQuil additionally causes drowsiness to assist you get rest.

Mucinex and NyQuil Cold & Flu are just for human being 12 years and also older. However, NyQuil has actually other commodities that are specifically made for children ages 4 to 11 years.

The encourage dosage for each drug varies according to the form. Follow the encourage dosage top top the parcel of whatever form you choose. You will must ask your medical professional for the exactly dosage the NyQuil to give to youngsters who room 4 come 11 year old.

Mucinex does not have the hazard of severe side effects. However, the following serious side effects may be feasible with NyQuil:

vision problems, such together blurry visiondifficulty urinatingallergic reaction, with symptoms together as:red, peeling or blistering skinrashhivesitchingswelling of the face, throat, tongue, lips, eyes, hands, or lower legsdifficulty breathing or swallowing

If you have serious side effects, you need to stop utilizing the drug and also call her doctor.


Drug interactions can increase or diminish the result of the various other medications. Interactions can likewise increase your threat of next effects. There are no known far-ranging interactions with guaifenesin, the energetic ingredient in Mucinex. However, all three energetic ingredients of NyQuil connect with other drugs.

Acetaminophen can connect with:

warfarinisoniazidcarbamazepine (Tegretol)phenobarbitalphenytoin (Dilantin)phenothiazines

Dextromethorphan can interact with:

isocarboxazidphenelzine (Nardil)selegilinetranylcypromine (Parnate)

Doxylamine can interact with:

isocarboxazidphenelzine selegilinetranylcyprominelinezolidopioids such together fentanyl, hydrocodone, methadone, and also morphine

You shouldn’t use Mucinex or NyQuil to treat a irreversible cough. Utilizing too much can reason harmful effects. You additionally shouldn’t usage these commodities to treat symptom of any type of medical condition you have without talk to your medical professional first.

Other conditions

Other problems you may have can impact how NyQuil functions for you. In part conditions, this drug deserve to be harmful. Questioning a doctor prior to using NyQuil if you have:

liver diseaseglaucomaurinating because of enlarged prostate gland


Don’t usage Mucinex or NyQuil for much longer than seven days. If her symptoms aren’t relieved after ~ a week, call your doctor and also stop utilizing these drugs.

NyQuil includes acetaminophen, which deserve to cause significant liver damages if you overuse it. Taking an ext than four doses of NyQuil in 24 hours can cause severe liver damage. Plenty of over-the-counter drugs additionally contain acetaminophen. If you take it NyQuil, make sure you don’t take it with various other drugs that contain acetaminophen. This will help make sure you nothing accidentally usage too much of the drug.

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Mucinex and also NyQuil room both commodities that relieve symptoms of the common cold or flu. The symptoms they treat are different. You have the right to take Mucinex and also NyQuil with each other safely if you follow the encourage dosage for each drug. However, acquisition Mucinex at night v NyQuil can actually store you native falling asleep. Mucinex will loosen your mucus, which can cause you to wake approximately cough.

Deciding between the two may simply mean picking the medicine that treats the symptom that are bothering you the most. That course, you should never take any type of drug if you’re no sure just how to usage it or if it’s right for you. Constantly talk come your medical professional if you have actually questions.